Slowing of cortical somatosensory evoked activity by Δ9-tetrahydrocannabinol and dimethylheptylpyran in alpha-chloralose-anesthetized cats

  title={Slowing of cortical somatosensory evoked activity by $\Delta$9-tetrahydrocannabinol and dimethylheptylpyran in alpha-chloralose-anesthetized cats},
  author={D. Wilkison and N. Pontzer and M. Hosko},
Somatosensory and visual evoked potentials in the classical afferent primary pathways in cats anesthetized with alpha-chloralose were studied in order to characterize the effects of delta 9-tetrahydrocannabinol (THC) and the synthetic analog, dimethylheptylpyran (DMHP) on central sensory processing. THC and DMHP slowed primary cortical responses to radial nerve or ventralis posterolateralis (VPL) stimulation in a dose dependent manner. THC did not alter VPL activity evoked by radial nerve… Expand
Inhibition of heterosensory thalamocortical evoked potentials by Δ-9-tetrahydrocannabinol
The effects of delta-9-tetrahydrocannabinol on sensory activity in the thalamic intralaminar nuclei, centralis lateralis and the mesencephalic reticular formation were compared with the effects onExpand
Alteration of electrical correlates of sensory processing by tetrahydrocannabinol
Sensory evoked multiple-unit activity showed a pattern of change after THC consistent with a reduction in activity of pyramidal output cells and a concomitant increase in interneuron activity, which is important in attention and orientation. Expand
the actions of THC on the intact hippocampus: A comparison of dentate and CA1 responses
In urethane-anesthetized rats, THC produced a shift to the right in the input/output relationship without altering the relation between the measures of synaptic wave and the population spike of the CA1 response to contralateral CA3 stimulation, suggesting alterations in limbic electrophysiology induced by THC may be mediated by structures other than the hippocampus. Expand
Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons.
It is found that inducing activity in layer 5 PNs resulted in endocannabinoid-mediated depolarization-induced suppression of excitation (DSE), whereas the majority of inhibitory inputs were cannabinoid insensitive, suggesting specificity of cannabinoid signaling across glutamatergic inputs. Expand
Effects of intraocular mescaline and LSD on visual-evoked responses in the rat
The effects of mescaline and LSD on the flash-evoked cortical potential (FEP) were determined in unrestrained rats with chronically-implanted electrodes and suggest that they produce deficits in conduction through the retino-geniculato-cortical system. Expand
THEMED ISSUE: CANNABINOIDS RESEARCH PAPER Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex
Background and purpose: In vitro studies demonstrate that cannabinoid CB1 receptors subserve activity-dependent suppression of inhibition in the neocortex. To examine this mechanism in vivo, weExpand
Δ9-Tetrahydrocannabinol alters cerebral metabolism in a biphasic, dose-dependent mannier in rat brain
Abstract Δ 9 -tetrahydrocannabinol (THC)-induced alterations in limbic and neocortical function are associated with deficiencies in short-term memory and recall. The 2-deoxy-D-glucose (2DG)Expand
The CB1 receptor antagonist SR141716 enhances stimulus-induced activation of the primary somatosensory cortex of the rat
Several recent studies have demonstrated a neuromodulatory role for endocannabinoids via their ability to act as retrograde inhibitors of synaptic neurotransmission. We utilized the functionalExpand
Effect of Cannabinoid Receptor Activation on Spreading Depression
Suppression of CSD by activation of CB1 receptors points to the potential therapeutic effects of cannabinoids in migraine with aura. Expand
Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex
This work assessed the effects of local changes in CB1 receptor activity on somatosensory cortex neuronal activation by whisker movement in rats to examine the mechanism in vivo. Expand


Effects of two tetrahydrocannabinols and of pentobarbital on cortico-cortical evoked responses in the squirrel monkey.
It is suggested that the increased responsiveness of cortical areas produced by the THC9s without the concomitant decrease of recovery produced by pentobarbital may be related to the changes in sensory perception produced by this group of cannabinoids. Expand
The effects of some drugs on an evoked response sensitive to tetrahydrocannabinols.
The effects of Δ9-THC and mescaline on responses in polysensory cortex are similar to those of certain convulsants but are unlike those of depressants or of amphetamine, levarterenol, lysergic acid diethylamide, phencyclidine or strychnine. Expand
Cannabinoid-induced enhancement and depression of cat monosynaptic reflexes
Direct evidence is provided that the cannabinoids produce both excitatory and depressant effects on central synaptic transmission, consistent with the well-documented effects of the cannabinoids on CNS excitability. Expand
Effects of mescaline, [delta9]-tetrahydrocannabinol and pentobarbital on the auditory evoked responses in the cat.
The effects of the hallucinogens, mescaline and [ Δ 9 ]-THC thus appear to resemble those of pentobarbital, a central nervous system depressant; however the mechanism of their actions differs. Expand
Cannabis and epilepsy.
CBD's unique anticonvulsant properties and its relative lack of known toxicity combine to enhance its potential as an antiepileptic drug. Expand
Effects of orally administered delta‐9‐tetrahydrocannabinol in man
The etfects of Δ9‐tetrahydrocannabinol administered orally at 2 dose levels were studied in a group of 7 healthy young adult males and caused hyperreflexia and upset postural responses in the absence of visual cues. Expand
Marihuana and epilepsy: paradoxical anticonvulsant and convulsant effects.
  • D. Feeney
  • Medicine
  • Advances in the biosciences
  • 1978
Epileptics should be discouraged from using marihuana since there is some risk of provoking seizures, but because of anticonvulsant potency and lack of convulsant or psychotropic action, cannabidiol should receive clinical trials with epileptic humans as a test of its anticonVulsant effectiveness. Expand
Comparison of tetrahydrocannabinol and synhexyl in man
These drugs differed from LSD in the following respects: sedation was prominent; euphoria was langer lasting; dreamlike sequences more pronounced; and physiological and biochemical effects were somewhat different, especially in the absence of sympathomimetic effects. Expand
Technique for rapid, permanent documentation of intracerebral electrode sites
  • M. Hosko
  • Medicine, Materials Science
  • Physiology & Behavior
  • 1975
Formalin fixed brains are blocked and frozen in 20% polyethylene glycol 6000 to expose electrode tracts and photographed on Polaroid film using a camera fitted with an extension bellows and macro lens for a permanent record of a selected section. Expand