Corpus ID: 32109598

Slowing evolution is more effective than enhancing drug development for managing resistance

  title={Slowing evolution is more effective than enhancing drug development for managing resistance},
  author={Nathan S. McClure and Troy Day},
  journal={arXiv: Populations and Evolution},
Drug resistance is a serious public health problem that threatens to thwart our ability to treat many infectious diseases. Repeatedly, the introduction of new drugs has been followed by the evolution of resistance. In principle there are two ways to address this problem: (i) enhancing drug development, and (ii) slowing drug resistance. We present data and a modeling approach based on queueing theory that explores how interventions aimed at these two facets affect the ability of the entire drug… Expand
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