Corpus ID: 32109598

Slowing evolution is more effective than enhancing drug development for managing resistance

@article{McClure2013SlowingEI,
  title={Slowing evolution is more effective than enhancing drug development for managing resistance},
  author={Nathan S. McClure and Troy Day},
  journal={arXiv: Populations and Evolution},
  year={2013}
}
Drug resistance is a serious public health problem that threatens to thwart our ability to treat many infectious diseases. Repeatedly, the introduction of new drugs has been followed by the evolution of resistance. In principle there are two ways to address this problem: (i) enhancing drug development, and (ii) slowing drug resistance. We present data and a modeling approach based on queueing theory that explores how interventions aimed at these two facets affect the ability of the entire drug… Expand
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References

SHOWING 1-10 OF 23 REFERENCES
Prospective strategies to delay the evolution of anti-malarial drug resistance: weighing the uncertainty
TLDR
There was a strong case for MFTs to guard against early failure because of uncertainty about the time to the emergence of ACT resistance, and the effects of reducing drug pressure in delaying appearance, reducing the chances of establishment, and slowing spread. Expand
Population biological principles of drug-resistance evolution in infectious diseases.
TLDR
Improved understanding of generic versus specific population biological aspects will help to translate results between different studies, and allow development of a more rational basis for sustainable drug use than exists at present. Expand
Benefits of using multiple first-line therapies against malaria
TLDR
An evolutionary-epidemiological modeling framework for malaria is designed and shows that the population-wide use of multiple first-line therapies against malaria yields a better clinical outcome than using a single therapy or a cycling strategy where therapies are rotated, either on a fixed cycling schedule or when resistance levels or treatment failure become too high. Expand
The future challenges facing the development of new antimicrobial drugs
TLDR
This work focuses primarily on an alternative novel strategy for antibacterial drug development that could potentially alleviate the current situation of drug resistance — targeting non-multiplying latent bacteria, which prolong the duration of antimicrobial chemotherapy and so might increase the rate of development of resistance. Expand
Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV
TLDR
The similarities and differences in the evolution of drug resistance for tuberculosis, malaria, and HIV-1 are summarized. Expand
Targeting virulence: a new paradigm for antimicrobial therapy
TLDR
It is proposed that in addition to targeting virulence, new antimicrobial development strategies should be expanded to include targeting bacterial gene functions that are essential for in vivo viability. Expand
Antimicrobial stewardship: concepts and strategies in the 21st century.
  • R. Owens
  • Medicine
  • Diagnostic microbiology and infectious disease
  • 2008
TLDR
The development of an effective antimicrobial stewardship program and the key components and operating principles are outlined, and insight into the production of materials that will facilitate the execution of these programs at healthcare facilities is provided. Expand
Epidemiology of drug-resistant malaria.
TLDR
The various features of drug resistance in Plasmodium falciparum, including its determinants, current status in diverse geographical areas, molecular markers, and their implications are described. Expand
Combination therapies for combating antimicrobial resistance.
  • M. Fischbach
  • Biology, Medicine
  • Current opinion in microbiology
  • 2011
TLDR
This perspective is to highlight one such strategy: treating infections with sets of drugs rather than individual drugs, and considers examples of naturally occurring combination therapies produced by micro-organisms. Expand
Antimalarial drug use in general populations of tropical Africa
TLDR
Antimalarial drug pressure varied considerably from one site to another, and was significantly higher in areas with intermediate malaria transmission level and in the most accessible sites. Expand
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