Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10.

Abstract

Slowed nerve-conduction velocities (NCVs) are a biological endophenotype in the majority of the hereditary motor and sensory neuropathies (HMSN). Here, we identified a family with autosomal dominant segregation of slowed NCVs without the clinical phenotype of HMSN. Peripheral-nerve biopsy showed predominantly thinly myelinated axons. We identified a locus… (More)

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Cite this paper

@article{Verhoeven2003SlowedCA, title={Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10.}, author={Kristien J Verhoeven and Peter de Jonghe and Tom van de Putte and Eva Nelis and An Zwijsen and Nathalie Verpoorten and Els De Vriendt and An Jacobs and Veerle Van Gerwen and Annick Francis and Chantal Ceuterick and Danny Huylebroeck and Vincent Timmerman}, journal={American journal of human genetics}, year={2003}, volume={73 4}, pages={926-32} }