Slowed Relaxation in Fatigued Skeletal Muscle Fibers of Xenopus and Mouse

@article{Westerblad1997SlowedRI,
  title={Slowed Relaxation in Fatigued Skeletal Muscle Fibers of Xenopus and Mouse  },
  author={H{\aa}kan Westerblad and Jan L{\"a}nnergren and David G. Allen},
  journal={The Journal of General Physiology},
  year={1997},
  volume={109},
  pages={385 - 399}
}
Slowing of relaxation is an important characteristic of skeletal muscle fatigue. The aim of the present study was to quantify the relative contribution of altered Ca2+ handling (calcium component) and factors downstream to Ca2+ (cross-bridge component) to the slowing of relaxation in fatigued fibers of Xenopus and mouse. Two types of Xenopus fibers were used: easily fatigued, type 1 fibers and fatigue resistant, type 2 fibers. In these Xenopus fibers the free myoplasmic [Ca2+] ([Ca2+]i) was… CONTINUE READING

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