Slow wave sleep and a state resembling absence epilepsy induced in the rat by gamma-hydroxybutyrate.

@article{Godschalk1977SlowWS,
  title={Slow wave sleep and a state resembling absence epilepsy induced in the rat by gamma-hydroxybutyrate.},
  author={Michael Godschalk and Mihailo Dzoljic and Iv{\'a}n L. Bonta},
  journal={European journal of pharmacology},
  year={1977},
  volume={44 2},
  pages={105-11}
}
The effect of gamma-hydroxybutyrate (GHB) in relatively low doses (12.5--200 mg/kg) on sleep stages, electrocorticogram (ECoG) patterns and behavior was investigated in the rat. 50-100 mg/kg GHB induced slow wave sleep but, in contrast to the cat, not paradoxical sleep. 200 mg/kg induced a hypersynchronous, bilaterally symmetrical ECoG pattern, which was different in amplitude and frequency distribution from normally occurring high amplitude patterns. When the hypersynchrony occurred in bursts… CONTINUE READING

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