Slow-wave activity saturation and thalamocortical isolation during propofol anesthesia in humans.

@article{Mhuircheartaigh2013SlowwaveAS,
  title={Slow-wave activity saturation and thalamocortical isolation during propofol anesthesia in humans.},
  author={R{\'o}is{\'i}n N{\'i} Mhuircheartaigh and Catherine Elizabeth Warnaby and Richard Rogers and Sa{\^a}d Jbabdi and Irene Tracey},
  journal={Science translational medicine},
  year={2013},
  volume={5 208},
  pages={208ra148}
}
The altered state of consciousness produced by general anesthetics is associated with a variety of changes in the brain's electrical activity. Under hyperpolarizing influences such as anesthetic drugs, cortical neurons oscillate at ~1 Hz, which is measurable as slow waves in the electroencephalogram (EEG). We have administered propofol anesthesia to 16 subjects and found that, after they had lost behavioral responsiveness (response to standard sensory stimuli), each individual's EEG slow-wave… CONTINUE READING
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Unresponsiveness ≠ unconsciousness

  • J. D. Gabrieli N. Gaab, G. H. Glover
  • Anesthesiology
  • 2012

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