Slow virus replication: the role of macrophages in the persistence and expression of visna viruses of sheep and goats.

@article{Narayan1982SlowVR,
  title={Slow virus replication: the role of macrophages in the persistence and expression of visna viruses of sheep and goats.},
  author={Opendra Narayan and Jerry S. Wolinsky and Janice E. Clements and John D. Strandberg and Diane E Griffin and Linda Collins Cork},
  journal={The Journal of general virology},
  year={1982},
  volume={59 Pt 2},
  pages={345-56}
}
Lentiviruses of sheep and goats cause slowly progressive diseases of the central nervous system (visna), lungs (maedi) and joints (arthritis) in their natural hosts. However, the virus target cell(s) in these diseases are still unknown. In this report, using laboratory-adapted Icelandic visna virus and several field strains recently obtained from sheep and goats with natural disease in the U.S.A., we show that macrophages became persistently infected when inoculated in culture. Furthermore… CONTINUE READING