Slow transport of unpolymerized tubulin and polymerized neurofilament in the squid giant axon.

@article{Galbraith1999SlowTO,
  title={Slow transport of unpolymerized tubulin and polymerized neurofilament in the squid giant axon.},
  author={James A Galbraith and Thomas S. Reese and Michelle L. Schlief and Paul E. Gallant},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 20},
  pages={11589-94}
}
A major issue in the slow transport of cytoskeletal proteins is the form in which they are transported. We have investigated the possibility that unpolymerized as well as polymerized cytoskeletal proteins can be actively transported in axons. We report the active transport of highly diffusible tubulin oligomers, as well as transport of the less diffusible neurofilament polymers. After injection into the squid giant axon, tubulin was transported in an anterograde direction at an average rate of… CONTINUE READING

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