Slow skeletal troponin I gene transfer, expression, and myofilament incorporation enhances adult cardiac myocyte contractile function.

@article{Westfall1997SlowST,
  title={Slow skeletal troponin I gene transfer, expression, and myofilament incorporation enhances adult cardiac myocyte contractile function.},
  author={Margaret V. Westfall and Elizabeth M. Rust and Joseph M Metzger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 10},
  pages={5444-9}
}
The functional significance of the developmental transition from slow skeletal troponin I (ssTnI) to cardiac TnI (cTnI) isoform expression in cardiac myocytes remains unclear. We show here the effects of adenovirus-mediated ssTnI gene transfer on myofilament structure and function in adult cardiac myocytes in primary culture. Gene transfer resulted in the rapid, uniform, and nearly complete replacement of endogenous cTnI with the ssTnI isoform with no detected changes in sarcomeric… CONTINUE READING
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