Slow oscillations of free intracellular calcium ion concentration in human fibroblasts responding to mechanical stretch.

@article{Arora1994SlowOO,
  title={Slow oscillations of free intracellular calcium ion concentration in human fibroblasts responding to mechanical stretch.},
  author={Pamela D. Arora and K J Bibby and C A McCulloch},
  journal={Journal of cellular physiology},
  year={1994},
  volume={161 2},
  pages={
          187-200
        }
}
Calcium transients in single, human gingival fibroblasts were studied after mechanical stretching of flexible culture substrates. A model system was developed to reproducibly stretch and rapidly (<1 sec) refocus cells in the same focal plane so that changes in the concentration of free intracellular calcium ions ([Ca2+]i) were monitored without delay. Attached cells were grown on flexible bottom Petriperm dishes, loaded with fura-2/AM, and stretched by 1% or 2.8% of substrate area. The stretch… CONTINUE READING
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