Slow oscillating population activity in developing cortical networks: models and experimental results.

@article{Baltz2011SlowOP,
  title={Slow oscillating population activity in developing cortical networks: models and experimental results.},
  author={Thomas Baltz and Andreas Herzog and Thomas B. Voigt},
  journal={Journal of neurophysiology},
  year={2011},
  volume={106 3},
  pages={
          1500-14
        }
}
During early development neuronal networks express slow oscillating synchronized activity. The activity can be driven by several, not necessarily mutually exclusive, mechanisms. Each mechanism might have distinctive consequences for the phenomenology, formation, or sustainment of the early activity pattern. Here we study the emergence of the oscillatory activity in three computational models and multisite extracellular recordings that we obtained from developing cortical networks in vitro. The… 
Analysis of cellular and synaptic mechanisms behind spontaneous cortical activity in vitro: Insights from optimization of spiking neuronal network models
TLDR
The role of synaptic mechanisms in shaping the neural population activity is studied by proposing a new method to combine experimental data and data-driven computational modeling based on spiking neuronal networks and bringing new understanding of the complex interplay between cellular, synaptic and network mechanisms supporting the burst dynamics.
Network Bursting Dynamics in Excitatory Cortical Neuron Cultures Results from the Combination of Different Adaptive Mechanism
In the brain, synchronization among cells of an assembly is a common phenomenon, and thought to be functionally relevant. Here we used an in vitro experimental model of cell assemblies, cortical
Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networks
TLDR
The results suggest that the presence of functional neuronal communities with recurrent local connections allows a neuronal system to generate spontaneous coordinated spiking activity events, as suggested by the rules used for implementing the computational model.
Size-dependent regulation of synchronized activity in living neuronal networks.
TLDR
The model shows that the decrease in total synaptic input to a neuron that drives the positive feedback amplification of correlated activity is a key factor underlying the destabilization of synchrony in smaller networks.
Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission
The modulation of neuronal activity by means of electrical stimulation is a successful therapeutic approach for patients suffering from a variety of central nervous system disorders. Prototypic
Network Events on Multiple Space and Time Scales in Cultured Neural Networks and in a Stochastic Rate Model
TLDR
A common probabilistic definition of network events is proposed that, applied to the firing activity of cultured neural networks, highlights the co-occurrence of network spikes, power-law distributed avalanches, and exponentially distributed ‘quasi-orbits’, which offer a third type of collective behavior.
Relationship between individual neuron and network spontaneous activity in developing mouse cortex.
TLDR
Simulations using a conductance-based network model demonstrated that a gradient of intrinsic excitability was sufficient to produce directionally propagating waves that replicated key experimental features, indicating that the higher level of cell-intrinsic activity in the piriform cortex may provide a substrate for SSA generation.
Unique Features of Network Bursts Emerge From the Complex Interplay of Excitatory and Inhibitory Receptors in Rat Neocortical Networks
TLDR
This study is the first to unravel in detail how the three main mediators of synaptic transmission uniquely shape the NB characteristics, such as the initiation, maintenance, recruitment and termination of NBs in cortical cell cultures in vitro.
The Structural E/I Balance Constrains the Early Development of Cortical Network Activity
TLDR
Results from additional networks generated with more diverse cellular composition, including early-born GABA neurons, suggest that a GABA-dependent mechanism may decrease the survival of additional INs, and suggest that the E/I balance of isolated postsynaptic currents in single cells may be regulated independently of PN/IN proportions, but the network bursts E-I balance and the maturation of spontaneous network activity critically depends upon the structural Pn/IN ratio.
Capturing remote activation of epilepsy source?
TLDR
Simulation results demonstrate the principle possibility of external, or remote, activation of a focal source of epileptic activity in the brain and suggest a generative mechanistic model of planar neuronal network, where the spatial configuration of pacemaker neurons is artificially engineered in order to resolve the problem.
...
1
2
3
...

References

SHOWING 1-10 OF 73 REFERENCES
Spontaneous development of synchronous oscillatory activity during maturation of cortical networks in vitro.
TLDR
It is shown that synchronous network activity depends on both glutamatergic and GABA(A)ergic neurotransmission during a brief period, and a period of synaptic depression after bursts is found that can explain the episodic nature of spontaneous network activity.
Network bursts in cortical cultures are best simulated using pacemaker neurons and adaptive synapses
TLDR
It is found that adding pacemaker-like neurons as well as adaptive synapses yield burst features in the same ranges as obtained experimentally, and it is demonstrated how changes in network connectivity, transmission delays, and excitatory fraction influence network burst features quantitatively.
Contribution of GABAergic Interneurons to the Development of Spontaneous Activity Patterns in Cultured Neocortical Networks
TLDR
It is suggested that the richly interconnected large GABAergic neurons contribute to desynchronize and temporally differentiate the spontaneous activity of cultured cortical networks.
Sequential Generation of Two Distinct Synapse-Driven Network Patterns in Developing Neocortex
TLDR
It is reported that the developing somatosensory cortex generates first ENOs then GDPs, both patterns coexisting for a restricted time period and it is shown that a tonic glutamate current contributes to the neuronal membrane excitability when cENOs dominate network patterns.
Spontaneous Correlated Activity in Developing Neural Circuits
t Synchrony Generation in Recurrent Networks with Frequency-Dependent Synapses
TLDR
It is found that the particular intensities of the external stimulus to specific neurons were crucial to evoke population bursts and therefore depends on the spectrum of basal discharge rates across the population and not on the anatomical individuality of the neurons, because this was random.
Timing of network synchronization by refractory mechanisms.
TLDR
The results associate the type of refractory mechanism with the temporal statistics and the mechanism of synchronization, thereby providing a framework for differentiating between cellular mechanisms of spontaneous rhythmogenesis.
Spontaneous coordinated activity in cultured networks: Analysis of multiple ignition sites, primary circuits, and burst phase delay distributions
TLDR
This work quantitatively analyzed the ignition and spread of collective spontaneous electrophysiological activity in networks of cultured cortical neurons growing on microelectrode arrays and produced specific quantitative constraints and insights into the activation patterns of collective neuronal activity in self-organized cortical networks, which may prove useful for models emulating spontaneously active systems.
Dissociated retinal neurons form periodically active synaptic circuits.
TLDR
Using calcium imaging and whole cell recording, it is shown that cultured dissociated mammalian retinal neurons form networks that produce spontaneous, correlated, highly periodic activity, and that synaptic depression may regulate the frequency of network activity.
...
1
2
3
4
5
...