Slow modal gating of single G protein-activated K+ channels expressed in Xenopus oocytes.

@article{Yakubovich2000SlowMG,
  title={Slow modal gating of single G protein-activated K+ channels expressed in Xenopus oocytes.},
  author={Daniel Yakubovich and Vassili F. Pastushenko and Arkady Bitler and Carmen W. Dessauer and Nathan Dascal},
  journal={The Journal of physiology},
  year={2000},
  volume={524 Pt 3},
  pages={737-55}
}
The slow kinetics of G protein-activated K+ (GIRK) channels expressed in Xenopus oocytes were studied in single-channel, inside-out membrane patches. Channels formed by GIRK1 plus GIRK4 subunits, which are known to form the cardiac acetylcholine (ACh)-activated GIRK channel (KACh), were activated by a near-saturating dose of G protein betagamma subunits (Gbetagamma; 20 nM). The kinetic parameters of the expressed GIRK1/4 channels were similar to those of cardiac KACh. GIRK1/4 channels differed… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Emergence of ion channel modal gating from independent subunit kinetics.

Proceedings of the National Academy of Sciences of the United States of America • 2016

Similar Papers

Loading similar papers…