Slow local movements of collagen fibers by fibroblasts drive the rapid global self-organization of collagen gels

@article{Sawhney2002SlowLM,
  title={Slow local movements of collagen fibers by fibroblasts drive the rapid global self-organization of collagen gels},
  author={Ravi K. Sawhney and Jonathon Howard},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={157},
  pages={1083 - 1092}
}
Aclassic model for tissue morphogenesis is the formation of ligament-like straps between explants of fibroblasts placed in collagen gels. The patterns arise from mechanical forces exerted by cells on their substrates (Harris et al., 1981). However, where do such straps come from, and how are slow local movements of cells transduced into dramatic long-distance redistributions of collagen? We embedded primary mouse skin and human periodontal ligament fibroblasts in collagen gels and measured the… CONTINUE READING

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Cell movements: from molecules to motility

  • D. Bray
  • Garland Publishing, New York. 372 pp.
  • 2001
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