Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress.

@article{Muro2003SlowIT,
  title={Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress.},
  author={Silvia Muro and Xiumin Cui and C. VanelleandD. Gajewski and J C Murciano and Vladimir R Muzykantov and Michael Koval},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={285 5},
  pages={
          C1339-47
        }
}
Nanotechnologies promise new means for drug delivery. ICAM-1 is a good target for vascular immunotargeting of nanoparticles to the perturbed endothelium, although endothelial cells do not internalize monomeric anti-ICAM-1 antibodies. However, coupling ICAM-1 antibodies to nanoparticles creates multivalent ligands that enter cells via an amiloride-sensitive endocytic pathway that does not require clathrin or caveolin. Fluorescence microscopy revealed that internalized anti-ICAM nanoparticles are… 
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ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs.

Two successive doses of anti-ICAM/NC/catalase protected ECs against H2O2 for at least 8 hours versus 2 hours afforded by a single dose, suggesting that recurrent targeting to ICAM-1 affords longer effects.

Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins.

NHE1 and NHE6 regulate distinct phases ofAnti-ICAM/NC uptake and trafficking; pharmacological agents affecting these regulatory elements alter the itinerary of anti-ICam/NC intracellular trafficking; and these agents modulate duration of the therapeutic effects of targeted drugs.

ICAM-1 targeting, intracellular trafficking, and functional activity of polymer nanocarriers coated with a fibrinogen-derived peptide for lysosomal enzyme replacement

Polymer nanocarriers coated with antibody against intercellular adhesion molecule 1 (ICAM-1), a protein overexpressed on most cells under disease states, enhanced biodistribution and lysosomal delivery of these therapeutics.

Distinct Subcellular Trafficking Resulting from Monomeric vs Multimeric Targeting to Endothelial ICAM-1: Implications for Drug Delivery

In conclusion, ICAM-1 can mediate different intracellular itineraries, revealing new insight into this biological pathway and alternative avenues for drug delivery.

Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers.

Carrier geometry was found to influence endothelial targeting in the vasculature, and the rate of endocytosis and lysosomal transport within ECs, and rational design of carrier geometry will help optimize endothelium-targeted therapeutics.

Lysosomal enzyme delivery by ICAM-1-targeted nanocarriers bypassing glycosylation- and clathrin-dependent endocytosis.

Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation.

OF SURFACTANT-FREE , FLUORESCENT POLY ( LACTIC-CO-GLYCOLIC ) ACID NANOPARTICLES TARGETED TO INTERCELLULAR ADHESION MOLECULE-1

Surfactant-free, FITC-labeled anti-ICAM PLGA NPs enabled the study of NP interactions with biological systems, which along with their fast degradation profile in physiologicallike conditions, will guide future therapeutic applications.

Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1.

Differential intra-endothelial delivery of polymer nanocarriers targeted to distinct PECAM-1 epitopes.

...

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