Slow integration leads to persistent action potential firing in distal axons of coupled interneurons.

@article{Sheffield2011SlowIL,
  title={Slow integration leads to persistent action potential firing in distal axons of coupled interneurons.},
  author={Mark E J Sheffield and Tyler K. Best and Brett D. Mensh and William L. Kath and Nelson Spruston},
  journal={Nature neuroscience},
  year={2011},
  volume={14 2},
  pages={
          200-7
        }
}
The conventional view of neurons is that synaptic inputs are integrated on a timescale of milliseconds to seconds in the dendrites, with action potential initiation occurring in the axon initial segment. We found a much slower form of integration that leads to action potential initiation in the distal axon, well beyond the initial segment. In a subset of rodent hippocampal and neocortical interneurons, hundreds of spikes, evoked over minutes, resulted in persistent firing that lasted for a… CONTINUE READING

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