Slow hyperpolarization in cortical neurons: a possible mechanism behind vagus nerve simulation therapy for refractory epilepsy?

@article{Zagon2000SlowHI,
  title={Slow hyperpolarization in cortical neurons: a possible mechanism behind vagus nerve simulation therapy for refractory epilepsy?},
  author={Aniko Zagon and Andreas A Kemeny},
  journal={Epilepsia},
  year={2000},
  volume={41 11},
  pages={1382-9}
}
PURPOSE Recent studies have shown that chronic, intermittent stimulation of the left vagus nerve (VNS) decreases the frequency, duration, and/or intensity of seizures in some patients with medically refractory focal seizures. Although VNS is being used in an increasing number of patients, the neuronal mechanism behind VNS therapy of refractory epileptic seizures is yet unclear. METHODS In vivo intracellular recordings were used to study responses elicited by the VNS in pyramidal neurons of… CONTINUE READING