Slow fractional removal of nonextractable iodine from rat tissue after injection of labeled L-thyroxine and 3,5,3'-triiodo-L-thyronine. A possible clue to the mechanism of initiation and persistence of hormonal action.


Previous studies have shown that a small but significant proportion of radioiodine from labeled L-thyroxine (T(4)) and 3,5,3'-triiodo-L-thyronine (T(3)) is incorporated into plasma and tissue proteins and is not, therefore, extractable with ethanol or other organic solvents. Other studies have shown that the complex consists, at least in part, of the… (More)


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