Slow-dissociation effect of common signaling subunit beta c on IL5 and GM-CSF receptor assembly.

Abstract

Receptor activation by IL5 and GM-CSF is a sequential process that depends on their interaction with a cytokine-specific subunit alpha and recruitment of a common signaling subunit beta (betac). In order to elucidate the assembly dynamics of these receptor subunits, we performed kinetic interaction analysis of the cytokine-receptor complex formation by a… (More)
DOI: 10.1016/j.cyto.2007.12.010

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