Slow desensitization of the human P2Y6 receptor.

  title={Slow desensitization of the human P2Y6 receptor.},
  author={Bernard Robaye and J. M. Boeynaems and Didier Communi},
  journal={European journal of pharmacology},
  volume={329 2-3},
The P2Y6 receptor is a recently cloned P2 receptor which displays a high sensitivity for diphosphonucleotides. In 1321N1 astrocytoma cells stably expressing this receptor, UDP induced a slow and sustained accumulation of inositol trisphosphate via a pertussis toxin-insensitive G-protein: the maximal level was only reached after 15 min and a significant response was maintained for at least 3 h. A full second response to UDP was obtained after the first 45-min stimulation, but was lost after 165… CONTINUE READING
26 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…