Slow-cycling/quiescence balance of hematopoietic stem cells is related to physiological gradient of oxygen.

@article{Guitart2010SlowcyclingquiescenceBO,
  title={Slow-cycling/quiescence balance of hematopoietic stem cells is related to physiological gradient of oxygen.},
  author={Amelie V Guitart and Mohammad Hammoud and Persio Dello Sbarba and Zoran Ivanovic and Vincent Praloran},
  journal={Experimental hematology},
  year={2010},
  volume={38 10},
  pages={847-51}
}
OBJECTIVE Regulation of hematopoiesis depends on cytokines, cellular interactions, transcription, and metabolic factors. Among the latter, O(2) has been neglected for a long time. Recently, an increasing number of publications evidenced the regulatory role of physiological low O(2) concentrations (0.1-5%; similar to those in bone marrow) on the in vitro behavior of hematopoietic stem cells. This brief review utilizes the article of Eliasson and colleagues in this Journal to summarize the major… CONTINUE READING

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