Slow currents through single sodium channels of the adult rat heart

@article{Patlak1985SlowCT,
  title={Slow currents through single sodium channels of the adult rat heart},
  author={Joseph B. Patlak and Mar{\'i}a Guadalupe Ram{\'i}rez Ortiz},
  journal={The Journal of General Physiology},
  year={1985},
  volume={86},
  pages={89 - 104}
}
The currents through single Na+ channels from the sarcolemma of ventricular cells dissociated from adult rat hearts were studied using the patch-clamp technique. All patches had several Na+ channels; most had 5-10, while some had up to 50 channels. At 10 degrees C, the conductance of the channel was 9.8 pS. The mean current for sets of many identical pulses inactivated exponentially with a time constant of 1.7 +/- 0.6 ms at -40 mV. Careful examination of the mean currents revealed a small, slow… CONTINUE READING

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