Slow conformational dynamics in the cystoviral RNA-directed RNA polymerase P2: influence of substrate nucleotides and template RNA.

Abstract

The RNA-directed RNA polymerase P2 from cystovirus ϕ6 catalyzes the de novo synthesis of positive and negative strands of the viral double-stranded RNA genome. P2 is mobile on the slow, microsecond to millisecond time scale with various motional modes, putatively assisting in RNA translocation and catalysis. Here we investigate the influence of the extreme… (More)
DOI: 10.1021/bi101863g

Topics

Cite this paper

@article{Ren2011SlowCD, title={Slow conformational dynamics in the cystoviral RNA-directed RNA polymerase P2: influence of substrate nucleotides and template RNA.}, author={Zhen Ren and Ranajeet Ghose}, journal={Biochemistry}, year={2011}, volume={50 11}, pages={1875-84} }