Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43.

@article{Rijen2004SlowCA,
  title={Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43.},
  author={Harold Victor Maria van Rijen and Dominik Eckardt and Joachim Degen and Martin Theis and Thomas Ott and Klaus Willecke and Habo J. Jongsma and Tobias Opthof and Jacques M. T. de Bakker},
  journal={Circulation},
  year={2004},
  volume={109 8},
  pages={1048-55}
}
BACKGROUND Connexin 43 (Cx43) is a major determinant of conduction in the ventricular working myocardium of mammals. We investigated the effect of decreased Cx43 expression on conduction velocity and arrhythmogenesis using adult mice with inducible deletion of Cx43. METHODS AND RESULTS Cx43Cre-ER(T)/+ mice, in which 1 coding region of the Cx43 gene was replaced by Cre-ER(T), were mated to Cx43fl/fl mice, generating Cx43Cre-ER(T)/fl mice. Application of 4-hydroxytamoxifen (4-OHT) induced Cre… CONTINUE READING
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Functional role of connexin 43 gap junction channels in adult mouse heart assessed by inducible gene deletion

  • D Eckhardt, M Theis, J Degen
  • J Mol Cell Cardiol
  • 2004

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