Slow-binding inhibition: the general case.

@article{Sculley1996SlowbindingIT,
  title={Slow-binding inhibition: the general case.},
  author={M J Sculley and Jonathan F Morrison and W. Wallace Cleland},
  journal={Biochimica et biophysica acta},
  year={1996},
  volume={1298 1},
  pages={78-86}
}
Two basic kinetic mechanisms have been described to account for the slow-binding inhibition of enzyme-catalyzed reactions. One mechanism involves the slow interaction of an inhibitor with enzyme (Mechanism A), while the other involves the rapid formation of an enzyme-inhibitor complex that undergoes a slow isomerization reaction (Mechanism B). But the initial interaction of enzyme and inhibitor may not necessarily be fast so that the free enzyme and the two forms of enzyme inhibitor complex are… CONTINUE READING

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