Slow- and fast-twitch rat hind limb skeletal muscle phenotypes 8 months after spinal cord transection and olfactory ensheathing glia transplantation.

@article{Negredo2008SlowAF,
  title={Slow- and fast-twitch rat hind limb skeletal muscle phenotypes 8 months after spinal cord transection and olfactory ensheathing glia transplantation.},
  author={Pilar Negredo and Jos{\'e}-Luis L Rivero and Beatriz Gonz{\'a}lez and Almudena Ram{\'o}n-Cueto and Rafael Manso},
  journal={The Journal of physiology},
  year={2008},
  volume={586 10},
  pages={2593-610}
}
Paralysed skeletal muscle of rats with spinal cord injury (SCI) undergoes atrophy and a switch in gene expression pattern which leads to faster, more fatigable phenotypes. Olfactory ensheathing glia (OEG) transplants have been reported to promote axonal regeneration and to restore sensory-motor function in animals with SCI. We hypothesized that OEG transplants could attenuate skeletal muscle phenotypic deterioration and that this effect could underlie the functional recovery observed in… CONTINUE READING
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