Slow actions of neuroactive steroids at GABAA receptors.

@article{Shu2004SlowAO,
  title={Slow actions of neuroactive steroids at GABAA receptors.},
  author={Hong-Jin Shu and Lawrence Eisenman and Deepani Jinadasa and Douglas F Covey and Charles F Zorumski and Steven J Mennerick},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 30},
  pages={6667-75}
}
Neuroactive steroids are potent and efficacious modulators of GABA(A) receptor activity and are potent sedatives and anesthetics. These positive modulators of GABA(A) receptors both potentiate the actions of GABA at the receptor and, at higher concentrations, directly gate the channel. The contribution of direct gating to the cellular and behavioral effects of neuroactive steroids is considered of little significance because it has been generally found that concentrations well above those… CONTINUE READING

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