Slo3 K+ Channels: Voltage and pH Dependence of Macroscopic Currents

  title={Slo3 K+ Channels: Voltage and pH Dependence of Macroscopic Currents},
  author={Xue Zhang and Xu-hui Zeng and Christopher J Lingle},
  journal={The Journal of General Physiology},
  pages={317 - 336}
The mouse Slo3 gene (KCNMA3) encodes a K(+) channel that is regulated by changes in cytosolic pH. Like Slo1 subunits responsible for the Ca(2+) and voltage-activated BK-type channel, the Slo3 alpha subunit contains a pore module with homology to voltage-gated K(+) channels and also an extensive cytosolic C terminus thought to be responsible for ligand dependence. For the Slo3 K(+) channel, increases in cytosolic pH promote channel activation, but very little is known about many fundamental… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 22 extracted citations


Publications referenced by this paper.
Showing 1-10 of 22 references

Crystal structure and mechanism of a calcium - gated potassium channel

  • A. Lee, J. Chen, V. Ruta, M. Cadene, B. T. Chait
  • Nature .
  • 2003

Localization of the Slack potassium channel in the rat central nervous system

  • W. J. Joiner, M. Wu, Y. Yang, F. J. Sigworth
  • J . Comp . Neurol .
  • 2003

Similar Papers

Loading similar papers…