Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity.

@article{Yiin2009Slit2IG,
  title={Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity.},
  author={Jia-Jean Yiin and Bo Hu and Michael J. Jarzynka and Haizhong Feng and Kui-Wei Liu and Jane Y Wu and Hsin-I Ma and Shi-Yuan Cheng},
  journal={Neuro-oncology},
  year={2009},
  volume={11 6},
  pages={
          779-89
        }
}
Acquisition of insidious invasiveness by malignant glioma cells involves multiple genetic alterations in signaling pathways. Slit2, a chemorepulsive factor, controls cell migration of neuronal and glial cells during development and inhibits chemotaxic migration of various types of cells in vitro. However, the role of Slit2 in vitro remains controversial, and the biological significance of Slit2 expression in cancer cell invasion in vivo has not yet been determined. In the present study, we… CONTINUE READING
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