Slit1b-Robo3 signaling and N-cadherin regulate apical process retraction in developing retinal ganglion cells.

@article{Wong2012Slit1bRobo3SA,
  title={Slit1b-Robo3 signaling and N-cadherin regulate apical process retraction in developing retinal ganglion cells.},
  author={Grace K. W. Wong and Marie-Laure Baudet and Caren Norden and Louis Leung and William A. Harris},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 1},
  pages={223-8}
}
When neurons exit the cell cycle after their terminal mitosis, they detach from the apical surface of the neuroepithelium. Despite the fact that this detachment is crucial for further neurogenesis and neuronal migration, the underlying mechanisms are still not understood. Here, taking advantage of the genetics and imaging possibilities of the zebrafish retina as a model system, we show by knockdown experiments that the guidance molecule Slit1b and its receptor Robo3 are required for apical… CONTINUE READING
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