Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome

@article{Kawachi2009SlitDD,
  title={Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome},
  author={Hiroshi Kawachi and Koichi Suzuki and Naoko Miyauchi and Taeko Hashimoto and Yasuhiro Otaki and Fujio Shimizu},
  journal={Clinical and Experimental Nephrology},
  year={2009},
  volume={13},
  pages={275-280}
}
Several recent studies have demonstrated that the slit diaphragm of the glomerular epithelial cell (podocyte) is the structure likely to be the principal barrier in the glomerular capillary wall. Nephrin identified as a gene product mutated in congenital nephrotic syndrome located at the outer leaflet of plasma membranes of the slit diaphragm. The anti… CONTINUE READING