Slit coordinates cardiac morphogenesis in Drosophila.

@article{MacMullin2006SlitCC,
  title={Slit coordinates cardiac morphogenesis in Drosophila.},
  author={Allison MacMullin and J Roger Jacobs},
  journal={Developmental biology},
  year={2006},
  volume={293 1},
  pages={
          154-64
        }
}
Slit is a secreted guidance cue that conveys repellent or attractive signals from target and guidepost cells. In Drosophila, responsive cells express one or more of three Robo receptors. The cardial cells of the developing heart express both Slit and Robo2. This is the first report of coincident expression of a Robo and its ligand. In slit mutants, cardial cell alignment, polarization and uniform migration are disrupted. The heart phenotype of robo2 mutants is similar, with fewer migration… CONTINUE READING

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