Slit-Robo Repulsive Signaling Extrudes Tumorigenic Cells from Epithelia.

@article{Vaughen2016SlitRoboRS,
  title={Slit-Robo Repulsive Signaling Extrudes Tumorigenic Cells from Epithelia.},
  author={John Vaughen and Tatsushi Igaki},
  journal={Developmental cell},
  year={2016},
  volume={39 6},
  pages={
          683-695
        }
}
Cells dynamically interact throughout animal development to coordinate growth and deter disease. For example, cell-cell competition weeds out aberrant cells to enforce homeostasis. In Drosophila, tumorigenic cells mutant for the cell polarity gene scribble (scrib) are actively eliminated from epithelia when surrounded by wild-type cells. While scrib cell elimination depends critically on JNK signaling, JNK-dependent cell death cannot sufficiently explain scrib cell extirpation. Thus, how JNK… CONTINUE READING
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