Slit Is the Midline Repellent for the Robo Receptor in Drosophila

@article{Kidd1999SlitIT,
  title={Slit Is the Midline Repellent for the Robo Receptor in Drosophila},
  author={Thomas Kidd and Kimberly S. Bland and Corey S. Goodman},
  journal={Cell},
  year={1999},
  volume={96},
  pages={785-794}
}
Previous studies suggested that Roundabout (Robo) is a repulsive guidance receptor on growth cones that binds to an unknown midline ligand. Here we present genetic evidence that Slit is the midline Robo ligand; a companion paper presents biochemical evidence that Slit binds Robo. Slit is a large extracellular matrix protein expressed by midline glia. In slit mutants, growth cones enter the midline but never leave it; they abnormally continue to express high levels of Robo while at the midline… CONTINUE READING
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