Slit-2 induces a tumor-suppressive effect by regulating beta-catenin in breast cancer cells.

@article{Prasad2008Slit2IA,
  title={Slit-2 induces a tumor-suppressive effect by regulating beta-catenin in breast cancer cells.},
  author={Anil Prasad and Vikram Paruchuri and Anju Preet and F. Latif and Ramesh Kumar Ganju},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 39},
  pages={26624-33}
}
SLIT-2 is considered as a candidate tumor suppressor gene, because it is frequently inactivated in various cancers due to hypermethylation of its promoter region and allelic loss. However, the exact mechanism of its tumor-suppressive effect has not been elucidated. Here, we observed that Slit-2-overexpressing breast cancer cells exhibited decreased proliferation and migration capabilities compared with control cells under in vitro conditions. These results were confirmed in vivo in mouse model… CONTINUE READING

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