Slipknotting upon native-like loop formation in a trefoil knot protein.

  title={Slipknotting upon native-like loop formation in a trefoil knot protein.},
  author={Jeffrey K. Noel and Joanna I. Sułkowska and Jos{\'e} N. Onuchic},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 35},
Protein knots and slipknots, mostly regarded as intriguing oddities, are gradually being recognized as significant structural motifs. Recent experimental results show that knotting, starting from a fully extended polypeptide, has not yet been observed. Understanding the nucleation process of folding knots is thus a natural challenge for both experimental and theoretical investigation. In this study, we employ energy landscape theory and molecular dynamics to elucidate the entire folding… CONTINUE READING


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