Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex.

Abstract

Nucleocytoplasmic transport is mediated by the interaction of transport factors (TFs) with disordered phenylalanine-glycine (FG) repeats that fill the central channel of the nuclear pore complex (NPC). However, the mechanism by which TFs rapidly diffuse through multiple FG repeats without compromising NPC selectivity is not yet fully understood. In this… (More)
DOI: 10.1073/pnas.1522663113

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