Slice cultures from head and neck squamous cell carcinoma: a novel test system for drug susceptibility and mechanisms of resistance

@inproceedings{Gerlach2014SliceCF,
  title={Slice cultures from head and neck squamous cell carcinoma: a novel test system for drug susceptibility and mechanisms of resistance},
  author={Moritz Gerlach and Felicitas Merz and Gunnar Wichmann and Christoph Kubick and Christian. Wittekind and Florian Lordick and Andreas Dietz and Ingo Bechmann},
  booktitle={British Journal of Cancer},
  year={2014}
}
Background:Human head and neck squamous cell carcinoma (HNSCC) fundamentally vary in their susceptibility to different cytotoxic drugs and treatment modalities. There is at present no clinically accepted test system to predict the most effective therapy for an individual patient.Methods:Therefore, we established tumour-derived slice cultures which can be kept in vitro for at least 6 days. Upon treatment with cisplatin, docetaxel and cetuximab, slices were fixed and paraffin sections were cut… CONTINUE READING
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