Sleeping sickness. The Castellani-Bruce controversy

  title={Sleeping sickness. The Castellani-Bruce controversy},
  author={John Boyd},
  journal={Notes and Records of the Royal Society of London},
  pages={110 - 93}
  • J. Boyd
  • Published 1 June 1973
  • History
  • Notes and Records of the Royal Society of London
PROFESSOR Marchese Sir Aldo Castellani died, on 3 October 1971. In obituary notices of this remarkable man, it is stated that he discovered that ‘sleeping sickness’, one of the deadly diseases of tropical Africa, is caused by infection with the protozoal parasite now known as Trypanosoma gambiense This claim, which was vigorously maintained by Castellani himself, is by no means universally accepted. Castellani was undoubtedly the first to discover trypanosomes in the cerebro-spinal fluid of… 

Bacteria or parasite? the controversy over the etiology of sleeping sickness and the Portuguese participation, 1898-1904.

  • I. Amaral
  • History
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  • 2012
The etiology of sleeping sickness was unknown until the early twentieth century, and two British missions to study the disease in Entebbe led to a controversy in which Portugal was involved from 1898 to 1904, on the national and international circuits.

The Trypanosomiases I

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Some Episodes in the History of African Trypanosomiasis

  • W. Lumsden
  • Medicine
    Proceedings of the Royal Society of Medicine
  • 1974
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From trypanosomes to the nervous system, from molecules to behavior: A survey, on the occasion of the 90th anniversary of Castellani's discovery of the parasites in sleeping sickness

The findings recently obtained in an experimental model of African trypanosomiasis in the rat are presented, which could account for the disruption of endogenous rhythms in sleeping sickness and the molecular and cellular mechanisms of the interplay between the parasite and the host have been largely clarified.

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This essay explores how and why Ehrlich and his partners cooperated across nations and borders in their search for a drug that would cure the disease, and explores what effect the drug trials had on African patients in Entebbe, British Uganda, and in Brazzaville, the capital of French Equatorial Africa.

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There is a sense of cautious optimism that, if the lessons learnt over the past century are carefully applied, further gains can be made in controlling and eliminating the classical problems that characterised tropical medicine at the beginning of this century.

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  • M. Worboys
  • Geography, Medicine
    History of science; an annual review of literature, research and teaching
  • 1994
A partir de travaux d'historiens, l'A. etablit une etude comparative sur l'histoire de la maladie du sommeil en Afrique Centrale et Orientale

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In mid-century, the writer, contemplating a career in parasitology was taken aback when he found that extolled contemporary biologists disdained parasites or thought little of Parasitology as an intellectual subject, reflecting a lack of appreciation of the important role of parasites in generating evolutionary novelty and speciation.