Sleep-promoting effects of cerebrospinal fluid from sleep-deprived goats.

  title={Sleep-promoting effects of cerebrospinal fluid from sleep-deprived goats.},
  author={John R. Pappenheimer and Tracy B. Miller and C A Goodrich},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={58 2},
In 1913 Legendre and Pieron1 reported that injection of cerebrospinal fluid (CSF) from a sleep-deprived dog into the cisterna magna of a normal animal induced sleep in the recipient for 2-6 hours following the injection. Recipients of fluid from normal dogs remained alert. The "hypnotoxic" factor was said to be nondialyzable and thermolabile. The Pieron phenomenon was reinvestigated in 1939 by Schnedorf and Ivy,2 who reported positive results in 9 out of 20 trials. The experimental conditions… 

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