Sleep in schizophrenia patients and the effects of antipsychotic drugs.

@article{Monti2004SleepIS,
  title={Sleep in schizophrenia patients and the effects of antipsychotic drugs.},
  author={Jaime M. Monti and Daniela Monti},
  journal={Sleep medicine reviews},
  year={2004},
  volume={8 2},
  pages={
          133-48
        }
}
  • J. Monti, D. Monti
  • Published 1 April 2004
  • Psychology, Medicine
  • Sleep medicine reviews
Sleep disturbance in schizophrenia
TLDR
The majority of studies indicate that stage 4 sleep and rapid eye movement (REM) latency are reduced in schizophrenia, whereas REM sleep duration tends to remain unchanged, and the characterization of the neurotransmitter systems involved remains a challenging dilemma.
Sleep and circadian rhythm dysregulation in schizophrenia
[Sleep architecture in schizophrenia patients].
TLDR
The findings indicate that in addition to decreased REM sleep time, disturbances in sleep initiation and maintenance were prominent in the non-medicated schizophrenia patients.
The effect of typical and atypical antipsychotic drugs on sleep of schizophrenic patients
TLDR
A number of studies have reported data on effects of antipsychotic drugs on sleep measures in patients with psychiatric disorders and in healthy control groups, with generally similar patterns of improvement of sleep continuity measures reported across the various agents in this class.
GABAB Receptors, Schizophrenia and Sleep Dysfunction
TLDR
Evidence for the possible utility of GABAB receptor agonists for the treatment of subjective and objective sleep abnormalities related to schizophrenia is presented and their effects on sleep architecture, cognition and negative symptoms in patients with schizophrenia are investigated.
[Sleep and circadian rhythm disturbances in schizophrenia].
TLDR
Despite improvement of psychopathological symptoms, many patients with schizophrenia still present low daytime activity and clinically significant insomnia and/or daytime sleepiness, which deteriorates their functioning.
[Sleep quality and daytime sleepiness in schizophrenia spectrum disorders during antipsychotic treatment].
TLDR
Subjective feeling of EDS is common in patients treated with antipsychotics and the ESS scale allows to verify the patients' claims, and should be differentiated from sedation resulting from pharmacological treatment and fatigue that may be related to somatic or mental disorders.
GABA(B) receptors, schizophrenia and sleep dysfunction: a review of the relationship and its potential clinical and therapeutic implications.
TLDR
Evidence for the possible utility of GABA(B) receptor agonists for the treatment of subjective and objective sleep abnormalities related to schizophrenia and their effects on sleep architecture, cognition and negative symptoms in patients with schizophrenia is presented.
Atypical antipsychotics: sedation versus efficacy.
TLDR
The pharma-cokinetics and pharmacodynamics of atypical antipsychotics are important factors to consider in the risk-benefit analysis, as are dosing strategies and individual patient factors, and clinicians must decide which agents are most appropriate for which patients.
Treatment Options for Insomnia in Schizophrenia: A Systematic Review.
TLDR
All 4 studies have shown good benefit/risk ratios and reviewed options-melatonin, paliperidone, and eszopiclone-might represent valid options for residual insomnia in schizophrenia.
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References

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Sleep disturbance in schizophrenia
TLDR
The majority of studies indicate that stage 4 sleep and rapid eye movement (REM) latency are reduced in schizophrenia, whereas REM sleep duration tends to remain unchanged, and the characterization of the neurotransmitter systems involved remains a challenging dilemma.
Sleep disturbance in schizophrenia. A revisit.
TLDR
REM intensity measures and REM latency were found to differentiate significantly the schizoaffective group and may identify diagnostic subgroups of schizophrenia as well as predict which schizophrenic depressive syndrome or a concurrent affective syndrome.
Effects of typical antipsychotic drugs and risperidone on the quality of sleep in patients with schizophrenia: a pilot study.
TLDR
Improvement by risperidone may be related to 5-HT2A/2C receptor blockade; however, further controlled studies are required to confirm these results.
Sleep laboratory and clinical studies of the effects of triazolam, flunitrazepam and flurazepam in insomniac patients.
TLDR
Polysomnographic recordings allow the recognition of three normal sleep stages: wakefulness, NREM and REM sleep, and the benzodiazepines are the most frequently prescribed hypnotics.
All-night sleep studies of acute schizophrenics.
TLDR
The sleepschizophrenia paradigm became subject for the first time to experimental scrutiny, and most sleep studies with schizophrenics since then have focused on the REM state, comparing schizophrenics with their normal counterparts.
Sleep polygraphy in schizophrenia: Methodological issues
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