Sleep in Alzheimer's Disease - Beyond Amyloid.

  title={Sleep in Alzheimer's Disease - Beyond Amyloid.},
  author={Jerrah Holth and Tirth K. Patel and David M Holtzman},
  journal={Neurobiology of sleep and circadian rhythms},
Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of institutionalization. Like AD pathology, sleep abnormalities can appear years before cognitive decline and may be predictive of dementia. A bidirectional relationship between sleep and amyloid β (Aβ) has been well established with disturbed sleep and increased wakefulness leading to increased Aβ production and decreased Aβ clearance; whereas Aβ deposition is associated with increased wakefulness and sleep… CONTINUE READING
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