Sleep-endocrine effects of mifepristone and megestrol acetate in healthy men.

  title={Sleep-endocrine effects of mifepristone and megestrol acetate in healthy men.},
  author={K. Wiedemann and C. Lauer and M. Hirschmann and K. Knaudt and F. Holsboer},
  journal={The American journal of physiology},
  volume={274 1},
  • K. Wiedemann, C. Lauer, +2 authors F. Holsboer
  • Published 1998
  • Chemistry, Medicine
  • The American journal of physiology
  • Administration of steroid hormones was demonstrated to modulate the sleep electroencephalogram (EEG) and sleep-associated hormonal secretion in specific ways. The present study was conducted to compare the effects of mifepristone (Mif), a mixed glucocorticoid (GR) and progesterone receptor (PR) antagonist, and megestrol acetate (Meg), a PR agonist. Nine healthy men were pretreated with either placebo or 200 mg Mif or 320 mg Meg, or a combination of both. Changes in plasma adrenocorticotropic… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Sex, steroids, and sleep: a review.
    • 275
    • Open Access


    Publications referenced by this paper.
    Gluco- and antimineralocorticoid effects on human sleep: a role of central corticosteroid receptors.
    • 144
    • Open Access
    Effects of estrogens on sleep and psychological state of hypogonadal women.
    • 185
    Sleep endocrine effects of antigluco- and antimineralocorticoids in healthy males.
    • 27
    Endometrial and pituitary responses to the steroidal antiprogestin RU 486 in postmenopausal women.
    • 190
    Sleep and the sleep electroencephalogram across the menstrual cycle in young healthy women.
    • 245
    • Open Access
    Sleep patterns related to menstrual cycle phase and premenstrual affective symptoms.
    • 113
    • Open Access