Sleep disturbances in Ube3a maternal-deficient mice modeling Angelman syndrome

@article{Colas2005SleepDI,
  title={Sleep disturbances in Ube3a maternal-deficient mice modeling Angelman syndrome},
  author={Damien Colas and Joseph E. Wagstaff and Patrice Fort and Denise Salvert and Nicole Sarda},
  journal={Neurobiology of Disease},
  year={2005},
  volume={20},
  pages={471-478}
}
BACKGROUND Angelman syndrome (AS) is a severe neurodevelopmental disorder with electroencephalographic (EEG) abnormalities and sleep disturbances. It results from lack of the functional maternal allele of UBE3A, which encodes a ubiquitin-protein ligase. Different mechanisms of UBE3A inactivation correlate with clinical phenotypes of varying severity; the majority of cases of AS are due to a de novo maternal deletion of the 15q11-q13 region. METHODS Ube3a maternal-deficient mice (Ube3a m-/p… CONTINUE READING
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