Sleep disorders and multiple sclerosis: a clinical and polysomnography study.

Abstract

BACKGROUND Patients with multiple sclerosis (MS) report sleep disturbances (SD) and excessive daytime sleepiness (EDS) more frequently than the general population. Our objectives were to evaluate SD and EDS in MS patients and to test the reliability of subjective sleep questionnaires. METHODS Demographic and clinical characteristics of unselected consecutive patients with MS were collected. Different questionnaires were used to assess quality of sleep, daytime sleepiness, fatigue, anxiety, depression and quality of life (QoL). Nocturnal polysomnography and Multiple Sleep Latency Test (MSLT) were performed in 25 selected MS patients with fatigue and with or without EDS. RESULTS 205 MS patients were enrolled. More than half of the MS patients were classified as 'poor sleepers'. In multivariate analysis, SD were correlated with disability, fatigue, depression, QoL, and pain, but not with EDS. Subjective sleepiness evaluated with the Epworth Sleepiness Scale and SD with the Pittsburgh Sleep Quality Index were not correlated with the results of the objective assessments of vigilance (MSLT) and sleep. CONCLUSIONS SD and EDS are frequent among MS patients. Objective assessment of vigilance and sleep can be challenging but MS patients who are poor sleepers should receive immediate assessment and treatment in order to improve QoL.

DOI: 10.1159/000335076
01020201520162017
Citations per Year

Citation Velocity: 8

Averaging 8 citations per year over the last 3 years.

Learn more about how we calculate this metric in our FAQ.

Cite this paper

@article{Neau2012SleepDA, title={Sleep disorders and multiple sclerosis: a clinical and polysomnography study.}, author={Jean - Philippe Neau and Jo{\"{e}l Paquereau and Vanessa Auche and St{\'e}phane Mathis and Ga{\"{e}lle Goden{\`e}che and Jonathan Ciron and Nathalie Moinot and Gautier Bouche}, journal={European neurology}, year={2012}, volume={68 1}, pages={8-15} }