Sleep deprivation in the rat by the disk-over-water method

  title={Sleep deprivation in the rat by the disk-over-water method},
  author={Allan Rechtschaffen and Bernard M. Bergmann},
  journal={Behavioural Brain Research},

Total Sleep Deprivation Decreases Immobility In The Forced-Swim Test

An animal model of depression (the forced-swim test) was used to determine whether the effects of total sleep deprivation parallel those obtained with antidepressant drugs, and it is believed that this paradigm can be used to study the neurobiological mechanisms of rapid antidepressant effects induced by sleep deprivation.

Sleep Deprivation and Sleep Extension Are Physiological Effects of Sleep Depri vation in the Rat Mediated by Bacterial Invasion ?

The results showed no significant evidence of aerobic bacterial invasion early in TSD and no indication that the major effects of TSD were dependent upon aerobicacterial invasion.

Prolonged sleep fragmentation of mice exacerbates febrile responses to lipopolysaccharide

Increased food intake and changes in metabolic hormones in response to chronic sleep restriction alternated with short periods of sleep allowance.

Assessment of the metabolic consequences of a chronic sleep restriction protocol that modeled working weeks with restricted sleep time alternated by weekends with sleep allowance revealed that the alternation between periods of sleep restriction and sleep allowance leads to complex changes in food intake and body weight.

Consequences of sleep deprivation.

  • J. Orzeł-Gryglewska
  • Psychology
    International journal of occupational medicine and environmental health
  • 2010
Sleeplessness accounts for impaired perception, difficulties in keeping concentration, vision disturbances, slower reactions, as well as the appearance of microepisodes of sleep during wakefulness which lead to lower capabilities and efficiency of task performance and to increased number of errors.

Effects of method, duration, and sleep stage on rebounds from sleep deprivation in the rat.

Reexamination of published evidence relevant to "sleep intensity," including "negative rebounds," rebounds in other species, the effects of stress and fatigue, depth of sleep indicators, and extended sleep points out pitfalls in the designation of any specific pattern as intense sleep.

Sleep homeostasis in infant rats.

An automated method of sleep deprivation in which 5-day-old rats were shocked whenever the nuchal muscle became atonic is presented, providing the earliest demonstration of the homeostatic regulation of sleep in an altricial mammal.

Effect of Sleep Deprivation on Righting Reflex in the Rat Is Partially Reversed by Administration of Adenosine A 1 and A 2 Receptor Antagonists

The hypothesis that potentiating effects of sleep deprivation on LORR can be altered by adenosine A1 and A2a receptor antagonists is tested in rats, suggesting possible non–adenosine-mediated effects ofSleep deprivation.



Sleep deprivation in the rat: XII. Effect on ambient temperature choice.

The attempt by TSD rats to get warmer, in spite of an elevated Tb, indicates a raised setpoint for behavioral thermoregulation and suggests that the increase in EE was also, at least in part, an attempt to reach an elevated setpoint.

Sleep deprivation in the rat: XV. Ambient temperature choice in paradoxical sleep-deprived rats.

To evaluate changes in heat flow and TSET, EE, Tb and Tch were measured in five PSD rats and their yoked control (PSC) rats, which showed progressive increases in EE and decreases in Tb as in the earlier PSD study; Tch rose progressively.

Sleep deprivation in the rat: XI. The effect of guanethidine-induced sympathetic blockade on the sleep deprivation syndrome.

Apparently, NE-mediated sympathetic activation was not critical for increased EE in sleep-deprived rats, although a role for catecholamines cannot be ruled out.

Sleep deprivation in the rat: XVI. Effects in a light-dark cycle.

TSD produced the same changes during an LD schedule as during constant light, and the amplitude of the diurnal body temperature rhythm declined over the course of TSD and then almost completely recovered during the first day of recovery sleep.

Sleep deprivation in the rat: VIII. High EEG amplitude sleep deprivation.

Control studies indicated that the partial PS loss in HS2 D rats could not, in and of itself, account for all the pathological effects, however, an interaction of HS2D and partial PS Loss in producing pathological effects cannot be ruled out.

Sleep deprivation in the rat: V. Energy use and mediation.

Estimates of CO2 production by the doubly labelled water method of indirect calorimetry correlated with EE estimated from the caloric value of food, weight change, and wastes and confirmed an increase in EE during deprivation.

Sleep deprivation in the rat: X. Integration and discussion of the findings.

The results of a series of studies on total and selective sleep deprivation in the rat are integrated and several changes suggested that sleep may be necessary for effective thermoregulation.

Effect of total sleep deprivation on 5'-deiodinase activity of rat brown adipose tissue.

Observations indicate that total sleep deprivation is associated with a marked increase in BAT 5'D-II activity in both euthyroid and hyperthyroid rats, which is essential for full BAT thermogenic response.