Sleep deprivation in the rat: III. Total sleep deprivation.

@article{Everson1989SleepDI,
  title={Sleep deprivation in the rat: III. Total sleep deprivation.},
  author={Carol A. Everson and Bernard M. Bergmann and Allan Rechtschaffen},
  journal={Sleep},
  year={1989},
  volume={12 1},
  pages={
          13-21
        }
}
Ten rats were subjected to total sleep deprivation (TSD) by the disk apparatus. All TSD rats died or were sacrificed when death seemed imminent within 11-32 days. No anatomical cause of death was identified. All TSD rats showed a debilitated appearance, lesions on their tails and paws, and weight loss in spite of increased food intake. Their yoked control (TSC) rats remained healthy. Since dehydration was ruled out and several measures indicated accelerated use rather than failure to absorb… Expand
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The most prominent features of recovery sleep in all rats were immediate and large rebounds of paradoxical sleep to far above baseline levels, followed by lesser temporally extended rebounds. Expand
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TLDR
A key feature is a sleep deprivation apparatus in which an experimental and a yoked control rat are housed on opposite sides of a divided disk suspended over shallow water, forcing the experimental rat to walk to avoid being carried into the water. Expand
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