Sleep deprivation in depression: what do we know, where do we go?

@article{WirzJustice1999SleepDI,
  title={Sleep deprivation in depression: what do we know, where do we go?},
  author={Anna Wirz-Justice and Rutger H. Hoofdakker},
  journal={Biological Psychiatry},
  year={1999},
  volume={46},
  pages={445-453}
}
Manipulations of the sleep-wake cycle, whether of duration (total or partial sleep deprivation [SD]) or timing (partial SD, phase advance), have profound and rapid effects on depressed mood in 60% of all diagnostic subgroups of affective disorders. Relapse after recovery sleep is less when patients are receiving medication; it may be prevented by co-administration of lithium, pindolol, serotonergic antidepressants, bright light, or a subsequent phase advance procedure. Diurnal and day-to-day… Expand
Chronobiological therapy for mood disorders
TLDR
In recent years, an increasing literature about the safety and efficacy of chronobiological treatments in everyday psychiatric settings has supported the inclusion of these techniques among the first-line antidepressant strategies for patients affected by mood disorders. Expand
Influence of sleep-wake and circadian rhythm disturbances in psychiatric disorders.
  • D. Boivin
  • Psychology, Medicine
  • Journal of psychiatry & neuroscience : JPN
  • 2000
TLDR
The results have implications for analyzing diurnal variation of mood in unipolar and bipolar affective disorders and sleep disturbances in other major psychiatric conditions such as chronic schizophrenia. Expand
Therapeutic use of sleep deprivation in depression.
TLDR
Current opinion is that partial sleep deprivation in the second half of the night is equally effective as TSD, and new data cast doubt on the time-honoured conviction that REM sleep deprivation is more effective than non-REM SD. Expand
Chronobiology and mood disorders
TLDR
The clinical observations of diurnal variation of mood and early morning awakening in depression have been incorporated into established diagnostic systems, as has the seasonal modifier defining winter depression, and advances in chronobiology continue to contribute novel treatments for affective disorders. Expand
Depression: chronophysiology and chronotherapy
TLDR
The novel antidepressant, agomelatine, which combines the properties of a serotonin 5-HT2C antagonist and a melatonergic MT1/MT2 receptor agonist, has been found to be very effective for resetting the disturbed sleep/wake cycle and improving the clinical status of depressed patients. Expand
Delta sleep ratio as a predictor of sleep deprivation response in major depression.
The fast but short-lasting improvement of depressive symptoms by sleep deprivation (SD) in about 60% of patients with a major depressive disorder is well established, but the mechanisms of action areExpand
Sleep deprivation therapy for depression.
TLDR
Considering its safety,Sleep deprivation is the most widely documented rapid-onset antidepressant therapy, targeting the broadly defined depressive syndrome, and can now be considered among the first-line antidepressant treatment strategies for patients affected by mood disorders. Expand
Sleep and Sleep-Wake Manipulations in Bipolar Depression
TLDR
Work by others and the own studies indicate that sleep deprivation and a phase advance of the sleep period can be used to treat bipolar patients during the depressed phase, and the risk of a switch into hypomania or mania does not seem to be more pronounced than the risk with typical pharmacological antidepressant treatment. Expand
Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression
TLDR
The extent to which objective tests of sleep-wake cycles and circadian function can be used to identify a sub-class of patients with major depression who have disturbed circadian profiles is explored. Expand
Sleep Deprivation as a Therapy in Psychiatry
TLDR
Different methods for increasing and sustaining the efficacy of sleep deprivation via combinatorial strategies have been studied and nowadays sleep deprivation could be considered the most rapid antidepressant available today. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 90 REFERENCES
Advanced vs. normal sleep timing: effects on depressed mood after response to sleep deprivation in patients with a major depressive disorder.
TLDR
Polysomnographic data showed that normal sleep was characterized by a more pronounced improvement of sleep continuity and increased slow-wave sleep, and the normal sleep group showed a stronger decrease in REM sleep density than the advanced sleep group compared with baseline. Expand
A longitudinal study of sleep deprivation responses in depression; The variability is highly related to diurnal mood variability.
TLDR
Comparison of sleep deprivation effects within individuals revealed that the course of mood during the day prior to T SD is irrelevant for the TSD response, and a favourable response to TSD appeared to be related to the patient's propensity to show diurnal mood variations per se, irrespective of their direction. Expand
Microsleep during Partial Sleep Deprivation in Depression
TLDR
Accumulated MS may influence the SD-induced positive effects in depressed patients, and patients with a low cumulative amount of MS during PSD improved significantly in mood, CPP, and sleep pattern compared to the patients who showed only slight changes. Expand
Lithium sustains the acute antidepressant effects of sleep deprivation: Preliminary findings from a controlled study
TLDR
This study compared the abilities of four different treatments to induce a rapid and sustained antidepressant response in 16 depressed patients and found lithium plus early morning sleep deprivation produced a quicker response than lithium with the control sleep deprivation, and the response was sustained for at least 30 days. Expand
Is sleep deprivation useful in the treatment of depression?
TLDR
Although the literature appears to demonstrate the efficacy of sleep deprivation as a potentiation strategy, these treatment studies have substantial methodological shortcomings and well-designed pilot studies indicate that sleep deprivation may hasten the onset of action of thymoleptic medications. Expand
Phase advance of the circadian sleep-wake cycle as an antidepressant.
TLDR
In a phase-shift experiment, a depressed manic-depressive woman was twice brought out of depression for 2 weeks by advancing her sleep period so that she went to sleep and arose 6 hours earlier than usual. Expand
Effects of partial sleep deprivation on the diurnal variation of mood and motor activity in major depression
TLDR
Positive mood responders had greater improvement than nonresponders in POMS subscales of depression, tension, confusion, and anger and showed significantly higher levels of locomotor activity on the baseline pre-PSD day than did non responders. Expand
Can non-REM sleep be depressogenic?
TLDR
It is suggested that the suppression of non-REM sleep intensity is the common pathway in the set of experimental data on the antidepressant effects of sleep manipulations. Expand
How to preserve the antidepressive effect of sleep deprivation: A comparison of sleep phase advance and sleep phase delay
TLDR
The clinical effectiveness of TSD can be significantly improved by combining TSD with a following phase advance of the sleep period, as the improvement usually subsides after the next night of sleep. Expand
Improvement of depression by REM sleep deprivation. New findings and a theory.
TLDR
It is suggested that the depressive abnormalities represent a "damaged," weakened sleep cycle "oscillator" and its correlate, a circadian rhythm disturbance, and that REM sleep deprivation improved depression to the extent that it stimulated the oscillator and corrected one manifestation of the circadian rhythm disturbances. Expand
...
1
2
3
4
5
...