Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus

@article{Guan2004SleepDI,
  title={Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus},
  author={Zhiwei Guan and Xuwen Peng and Jidong Fang},
  journal={Brain Research},
  year={2004},
  volume={1018},
  pages={38-47}
}
Sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylation
TLDR
A relatively short SD during the normal resting phase may affect spatial working memory in mice by reducing hippocampal AMPA receptor function through a change in AKAP150 levels, which provides further insight into the possible mechanism of SD‐induced hippocampal dysfunction and memory impairment.
Sleep deprivation prevents learning-induced MAPK activation in the mouse hippocampus and impairs behavioral flexibility in a Y-maze task
TLDR
Data show that sleep loss during the learning phase of a task affects plasticity-related signaling in the hippocampus, which can hamper subsequent adaptation of this acquired memory when the situation changes.
Regular exercise prevents sleep deprivation associated impairment of long-term memory and synaptic plasticity in the CA1 area of the hippocampus.
TLDR
The results suggest that the exercise protocol may prevent 24-h S-D-induced impairments in long-term memory and LTP by preventing deleterious changes in the basal and post-stimulation levels of P-CREB and BDNF associated with S- D.
Brain-specific expression of cellular prion protein in memory impairment induced by sleep-deprivation in rats
TLDR
The findings suggest that the reduced PrPC level in the hippocampus contributes to sleep-deprivation induced hippocampal-dependent memory impairment; and CREB signaling pathway involves in this process.
Sleep deprivation impairs cAMP signaling in the hippocampus
TLDR
It is demonstrated that brief sleep deprivation disrupts hippocampal function by interfering with cAMP signalling through increased PDE4 activity, and drugs that enhance camp signalling may provide a new therapeutic approach to counteract the cognitive effects of sleep deprivation.
Coping with sleep deprivation: shifts in regional brain activity and learning strategy.
TLDR
Findings suggest that the brain compensates for negative effects of sleep deprivation on the hippocampal memory system by promoting the use of a striatal memory system.
Animal studies on the role of sleep in memory: from behavioral performance to molecular mechanisms.
TLDR
Experimental studies indicate that cognitive impairments as a consequence of sleep deprivation appear to be most severe with learning and memory processes that require the hippocampus, which suggests that this brain region is particularly sensitive to the consequences of sleep loss.
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The exposure of rats to 72 hr of primarily rapid eye movement SD impaired their subsequent performance on a hippocampus-dependent spatial learning task but had no effect on an amygdala-dependent learning task, suggesting that failure to acquire adequate sleep produces several molecular and cellular level alterations that profoundly inhibit hippocampal functioning.
Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning.
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Sleep deprivation from 0-5 h after training for this task impaired memory consolidation for contextual fear conditioning whereas sleep deprivation from 5-10H after training had no effect, suggesting that sleep deprivation may act by modifying these molecular mechanisms of memory storage.
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