Sleep deprivation impairs cAMP signaling in the hippocampus

  title={Sleep deprivation impairs cAMP signaling in the hippocampus},
  author={Christopher G. Vecsey and George S Baillie and Devan Jaganath and Robbert Havekes and Andrew Daniels and Mathieu E J Wimmer and Ted Huang and Kim M. Brown and Xiang-yao Li and Giannina Descalzi and Susan S. Kim and Tao Chen and Yu-Ze Shang and Min Zhuo and Miles D Houslay and Ted Abel},
Millions of people regularly obtain insufficient sleep. Given the effect of sleep deprivation on our lives, understanding the cellular and molecular pathways affected by sleep deprivation is clearly of social and clinical importance. One of the major effects of sleep deprivation on the brain is to produce memory deficits in learning models that are dependent on the hippocampus. Here we have identified a molecular mechanism by which brief sleep deprivation alters hippocampal function. Sleep… CONTINUE READING
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