Sleep deprivation as an experimental model system for psychosis: Effects on smooth pursuit, prosaccades, and antisaccades

@article{Meyhfer2017SleepDA,
  title={Sleep deprivation as an experimental model system for psychosis: Effects on smooth pursuit, prosaccades, and antisaccades},
  author={Inga Meyh{\"o}fer and Veena Kumari and Antje Hill and Nadine Petrovsky and Ulrich Ettinger},
  journal={Journal of Psychopharmacology},
  year={2017},
  volume={31},
  pages={418 - 433}
}
Current antipsychotic medications fail to satisfactorily reduce negative and cognitive symptoms and produce many unwanted side effects, necessitating the development of new compounds. Cross-species, experimental behavioural model systems can be valuable to inform the development of such drugs. The aim of the current study was to further test the hypothesis that controlled sleep deprivation is a safe and effective model system for psychosis when combined with oculomotor biomarkers of… 
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Combining two model systems of psychosis: The effects of schizotypy and sleep deprivation on oculomotor control and psychotomimetic states.
TLDR
It is concluded that oculomotor impairments are observed in relation to schizotypy and following sleep deprivation, supporting their utility as biomarkers in model systems of psychosis.
Controlled sleep deprivation as an experimental medicine model of schizophrenia: An update
Combining trait and state model systems of psychosis: The effect of sleep deprivation on cognitive functions in schizotypal individuals
Sleep, circadian rhythms, and schizophrenia: where we are and where we need to go
Purpose of review The review is designed to give an overview of the latest developments in research exploring the relationship between sleep and psychosis, with particular attention paid to the…
Neurobehavioural complications of sleep deprivation: Shedding light on the emerging role of neuroactive steroids
TLDR
This scenario suggests that the synthesis of neuroactive steroids during acute SD may be enacted as a neuroprotective response in the PFC; however, such compensation may in turn set off neurobehavioural complications by interfering with the corticolimbic connections responsible for executive functions and emotional regulation.
Severe Sleep Deprivation Causes Hallucinations and a Gradual Progression Toward Psychosis With Increasing Time Awake
TLDR
Psychotic symptoms develop with increasing time awake, from simple visual/somatosensory misperceptions to hallucinations and delusions, ending in a condition resembling acute psychosis.
Sleep and schizophrenia: From epiphenomenon to treatable causal target
Eye movements in patients in early psychosis with and without a history of cannabis use
TLDR
Data indicate that impairment of smooth pursuit in psychosis is more severe in patients without a history of cannabis use, consistent with the notion that the severity of neurobiological alterations in psychotic illness is lower in patients whose illness developed in the context of cannabisUse.
The Role of Endocannabinoid System in Sleep Deprivation-Induced Psychosis-Like Symptoms through Hampering Prepulse Inhibition; A Hypothesis
TLDR
The present hypothesis revolves around the question whether altered chemical dynamics within the eCB system with the resultant impact on cannabinoid receptors in key cortical hubs would impact SD-induced psychosis-like symptoms.
Sleep deprivation alters task‐related changes in functional connectivity of the frontal cortex: A near‐infrared spectroscopy study
TLDR
During task, SD resulted in a significantly smaller decrease in the number and strength of functional connections (characterizing FC) in the frontal cortex and changes in the global connection strengths correlated with decreased performance in the paired association learning test.
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